Of those mares bred, 59% were pregnant following an average of 1.4 services during that estrus. 7. IMPORTANT SAFETY INFORMATION FOR LUTALYSE: Women of childbearing age and persons with respiratory problems should exercise extreme caution when handling LUTALYSE. 4. For use with FACTREL® (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework: • Administer the first dose of FACTREL Injection (2-4 mL) at Day 0. No mortality occurred in any of the groups. All systems associated with dinoprost metabolism exist in the body; therefore, no new metabolic, transport, excretory, binding or other systems need be established by the body to metabolize injected dinoprost. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid. Earn continuing education credits and stay current on industry developments with Zoetis’ convenient, on-demand learning solutions. Additional studies investigated the effects in the mare of single intramuscular doses of 0, 0.25, 1.0, 2.5, 3.0, 5.0, and 10.0 mg dinoprost tromethamine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The smallness of the fetus at this early stage of gestation should not lead to complications at abortion. In the early stages, women may be unaware of their pregnancies. Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. The industry standard for in ovo technology. Cattle: LUTALYSE Injection is indicated as a luteolytic agent. Mares: The most frequently observed side effects are sweating and decreased rectal temperature. If estrus has not been observed by 80 hours after injection, breed at 80 hours. FACTREL® Injection (gonadorelin injection) is now approved for use with LUTALYSE to synchronize estrous cycles to allow for fixed-time artificial insemination (FTAI) in lactating dairy cows. LUTALYSE® Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. There was no evidence of toxicological effects. These effects are usually seen within 15 minutes of injection and disappear within one hour. This information is essential to determine the appropriate time for administration of LUTALYSE Injection. Difficult-to-Breed Mares: In extended diestrus there is failure to exhibit regular estrous cycles which is different from true anestrus. Do not use inserts more than once. For Difficult-to-Breed Mares: In one study with 122 Standardbred and Thoroughbred mares in clinical anestrus for an average of 58 days and treated during the breeding season, behavioral estrus was detected in 81 percent at an average time of 3.7 days after injection with 5 mg LUTALYSE Injection; ovulation occurred an average of 7.0 days after treatment. These side effects are transitory, lasting from 10 minutes to 3 hours, and were not detrimental to the health of the animal. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. Avoid contact with skin by wearing protective gloves when handling EAZI-BREED CIDR inserts. LUTALYSE® Injection (dinoprost tromethamine injection) is the most "veterinarian recommended" and "producer used" prostaglandin in the market.1 Artificial insemination synchronization programs with LUTALYSE can improve breeding success. The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. For Treatment of Pyometra (chronic endometritis) in Cattle: In studies conducted with LUTALYSE Injection, pyometra was defined as presence of a corpus luteum in the ovary and uterine horns containing fluid but not a conceptus based on palpation per rectum. Laboratory Animals: Dinoprost was non-teratogenic in rats when administered orally at 1.25, 3.2, 10.0 and 20.0 mg dinoprost/kg/day from day 6th-15th of gestation or when administered subcutaneously at 0.5 and 1.0 mg/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract. Controlling Time of Estrus of Estrous Cycling Mares: Mares treated with LUTALYSE Injection during diestrus (4 or more days after ovulation) will return to estrus within 2 to 4 days in most cases and ovulate 8 to 12 days after treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.For intramuscular use for estrus synchronization, treatment of unobserved (silent) estrus and pyometra (chronic endometritis) in cattle; for abortion of feedlot and other non-lactating cattle; for parturition induction in swine; and for controlling the timing of estrus in estrous cycling mares and clinically anestrous mares that have a corpus luteum. Neither heart rate nor respiration rates were significantly altered (P > 0.05) when compared to contemporary control values. Consequently, the information provided on the site in which you enter may not be suitable for use in your country. 1Animalytix Ruminant Segments & Equine MAT ending Jan 2015. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. Cattle that abort will abort within 35 days of injection. Metabolism: A number of metabolism studies have been done in laboratory animals. Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection. Following abortion, early fetal death and resorption, or as a result of “pseudopregnancy”, there may be serum progesterone levels consistent with a functional corpus luteum. Do not administer to sows and/or gilts prior to 3 days of normal predicted farrowing as an increased number of stillbirths and postnatal mortality may result. Use of this product in excess of the approved dose may result in drug residues. • Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection. In cattle, Lutalyse® is indicated for estrus synchronization, treatment of silent estrus, and treatment of pyometra (chronic edometritis). Available for Android and iOS devices. Prostaglandins, especially PGE’s and PGF’s, have been shown, in certain species, to 1) increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2) stimulate myometrial activity, and 3) to induce either abortion or parturition. Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. Do not use in heifers of insufficient size or age for breeding or in cattle with abnormal, immature, or infected genital tracts. We are Return to normal was defined as evacuation of fluid and return of the uterine horn size to 40mm or less based on palpation per rectum at 14 and 28 days.
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